健康

　　标题：Genemayamplifyimpactoflifeeventsonmentalhealth
　　source：medicalnewstoday丨byCatharinePaddockPhD
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　　Anewstudysuggeststhatwhileacertaingenevariantmaypredisposepeopletodepressionfollowingahistoryofbadlifeevents，suchaschildhoodabuse，thatsamegenemayalsoenhancehappinesswhenbadlifeeventsareabsent。
　　Thefindingchallengesatraditionalviewaboutthelinkbetweengeneticsanddepression，suggestDr。ChadBousmanandcolleagues，fromtheUniversityofMelbourneinAustralia，whoreporttheirworkintheBritishJournalofPsychiatryOpen。
　　Thetraditionalviewholdsthatifyoucarryaversionofagenethatislinkedtohigherriskofdepression，thenitmakesyoumorevulnerabletodepression。
　　ButthenewstudysuggestsitislessacaseofvulnerabilityandmoreacaseofplasticitywhatdeepensthenegativemayalsoheightenthepositiveasDr。Bousmanexplains：
　　Ourresultssuggestsomepeoplehaveageneticmakeupthatmakesthemmoresusceptibletonegativeenvironments，butifputinasupportiveenvironmentthesesamepeoplearelikelytothrive。
　　Theteamofpsychiatristsandgeneralpractitionerssuggeststhefindingshaveprofoundimplicationsforthetreatmentofdepression。
　　Youcantchangeyourgenotypeorgobackandchangeyourchildhood，butyoucantakestepstomodifyyourcurrentenvironment，saysDr。Bousman。Italsomeansthatitsnotasclearcutastellingapersonthatbecausetheyhaveariskgene，theyredoomed。Thisresearchisshowingthatsnotthecaseatall。
　　FirststudytoexaminelinkbetweenSERTandongoingseveredepressivesymptoms
　　Theresearcherswereinterestedinfindingoutwhysomeadultswithahistoryofchildhoodsexualorphysicalabusegoontodeveloplongtermdepression。
　　Thestudyisthefirsttoinvestigatehowacertaingenecaninfluencepeoplessensitivitytoenvironmentbyfollowingagroupofparticipantsovertime。
　　ThegenetheyinvestigatediscalledSERT。Itcodesforaproteinthattransportsthemoodregulatingchemicalserotonin。
　　EachofushasoneofthreeversionsofSERT：thelonglong（ll），theshortlong（sl）ortheshortshort（ss）version。
　　Forthestudy，theteamanalyzedtheDNAof333middleagedAustraliansofNorthernandWesternEuropeandescentandassessedthemforsymptomsofdepressionover5yearsusingamentalhealthquestionnairecalledPHQ9（thePrimaryCareEvaluationofMentalDisordersPatientHealthQuestionnaire）。
　　Theresultsshowedthatofthe23ofparticipantswiththessversionofSERT，thosewhohadahistoryofchildhoodabusewerethemostlikelytoexperienceongoingseveredepressivesymptomsinmiddleage。
　　However，carriersofthessversionofSERTwhodidnothaveahistoryofabusewerealsotheoneswhosementalhealthassessmentshowedthemtobehappierthantherestoftheparticipants。
　　Theresearcherssuggestthegenecouldbeusedtoassesspeoplessusceptibilitytodepression，particularlyiftheyhaveahistoryofchildabuse。Itcouldalsohelptoidentifypatientswhomayneedextrasupport。
　　Dr。Bousmansuggeststhefindingsalsoofferhopetopeoplewhoexperienceongoingclinicaldepression：geneticmakeupisnottheonlythingthatdetermineshowtheymightexperiencedepression。Heconcludes：
　　Thisresearchtellsusthatwhatmaybeconsideredariskgeneinonecontextmayactuallybebeneficialinanother。Sothisdirectlyopposesthenotionofgeneticdeterminism，theideathatyourgenesdefineyourfate。
　　Heandhiscolleaguesnowplantoextendtheirresearchtoseeifseveralgenesworkingtogetheralsohavethiseffect。
　　TheyalsopointoutthattheirstudywaslimitedtoparticipantsofNorthernandWesternEuropeandescent，andthefindingsmaynotapplytootherpopulations。
　　Meanwhile，MedicalNewsTodayhavelearnedofnewresearchthatsuggestsahealthydietmayreducetheriskofdepression。ABMCMedicinestudythatfollowedover15，000participantsfor10years，ledbytheUniversityofLasPalmasdeGranCanariainSpain，foundthatthosewhoatelotsoffruits，veges，nutsandlegumeshadareducedriskofdevelopingdepression。